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2019-11-14 高海春 - Distinct Nitrite and Nitric Oxide Physiologies in Bacteria
  发表时间:2019-11-08  阅读次数:422     发布者:19970040
报告题目:Distinct Nitrite and Nitric Oxide Physiologies in Bacteria
报告人:高海春 教授
主持人:吴电明 研究员
报告时间:2019年11月14日 9: 00 - 10: 00
报告地点:闵行校区河口海岸大楼A1011室
主办单位:地理科学学院、地理信息科学教育部重点实验室


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报告人简介:
       高海春,教授,国家‘万人计划’科技创新领军人才,北京大学生物学学士,中国科学院武汉病毒研究所微生物学硕士和普度大学(美国)博士。先后在美国橡树岭国家实验室、密歇根州立和俄克拉荷马大学进行研究,于2008年回国加入浙江大学。高海春课题组主要聚焦于系统解析无机和有机物降解模式菌奥内达希瓦氏的环境适应性及机制,关注呼吸途径及调控、不良环境应对机制及调控、和单细胞及群体生活方式的选择与调控等方面。以通讯作者身份发表SCI论文80余篇,其中在包括ISME J、Mol Microbiol、Environ Microbiol、J Biol Chem、J Bacteriol、和Appl Environ Microbiol等微生物权威期刊50余篇。研究成果在分子层面上加深了对环境微生物的理解,拓宽了环境微生物研究视野,整体水平居于国际前沿。

报告内容简介:
       Nitrite has been used in food preservation for centuries because it prevents bacterial growth. About 30 years ago, the effect was proposed to be mediated by nitric oxide (NO), an intermediate formed during nitrite reduction to nitrogen. Ever since, it has become an established theory in nitrite biology. However, by studying Shewanella oneidensis, a Gram-negative bacterium renowned for respiratory versatility, we found that this may not be the case, at least in some bacteria. Nitrite inhibits growth of S. oneidensis under either aerobic or anaerobic conditions. While the cytochrome c oxidase is primarily responsible for nitrite inhibition during oxygen respiration, the answers to inhibition of anaerobic growth are rather complex, involving both global regulator cAMP-Crp and a soluble cytochrome c NapB. In contrast, the targets of NO in bacteria are diverse. Bacteria Cytochromes c being most vulnerable.